8. Fundamental Principles of Cell-Based Assays

  1. Ge Wu

Published Online: 16 JUN 2010

DOI: 10.1002/9780470583128.ch8

Assay Development: Fundamentals and Practices

Assay Development: Fundamentals and Practices

How to Cite

Wu, G. (2010) Fundamental Principles of Cell-Based Assays, in Assay Development: Fundamentals and Practices, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470583128.ch8

Author Information

  1. La Canada Flintridge, California, USA

Publication History

  1. Published Online: 16 JUN 2010
  2. Published Print: 29 MAR 2010

ISBN Information

Print ISBN: 9780470191156

Online ISBN: 9780470583128



  • fundamental principles of cell-based assays;
  • cell-based assays and affinity and efficacy concepts;
  • separate cytotoxicity assay needed - in following up hits from cell-based assays


This chapter contains sections titled:

  • Cell Signaling, Signal Transduction, and Cellular Responses

  • General Approaches in Cell-Based Assays

  • Concept of Affinity and Efficacy in Cell-Based Assays

  • Development of Cell-Based Assays

  • Useful Websites

  • Bibliography