13. TRPV1 Agonist Approaches for Pain Management

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Keith R. Bley

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch13

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Bley, K. R. (2010) TRPV1 Agonist Approaches for Pain Management, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch13

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. NeurogesX, Inc., 2201 Bridgepointe Parkway, San Mateo, CA 94404, USA

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

SEARCH

Keywords:

  • TRPV1 agonist approaches for pain management;
  • TRPV1 agonist-induced disruption of nociceptor hyperactivity;
  • TRPV1 agonist-based therapies – viability unlikely, side-effect profile of defunctionalization, unlikely to be acceptable

Summary

This chapter contains sections titled:

  • Introduction

  • TRPV1 Agonist - Induced Nociceptor Defunctionalization

  • Nociceptor Hyperactivity

  • Bases for Nociceptor Hyperactivity

  • TRPV1 Agonist - Induced Disruption of Nociceptor Hyperactivity

  • Potential Indications for Locally Administered TRPV1 Agonists

  • Painful Peripheral Neuropathies

  • Traumatic and Musculoskeletal Pain

  • Migraine and Headache

  • Vulvodynia and Mucosal Disorders

  • Bladder Pain and Overactivity

  • Conclusions

  • References