14. The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Andras Garami1,
  2. Maria C. Almeida1,
  3. Tatiane B. Nucci1,
  4. Tamara Hew-Butler1,
  5. Renato N. Soriano1,
  6. Eszter Pakai1,
  7. Kazuhiro Nakamura2,
  8. Shaun F. Morrison2 and
  9. Andrej A. Romanovsky1

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch14

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Garami, A., Almeida, M. C., Nucci, T. B., Hew-Butler, T., Soriano, R. N., Pakai, E., Nakamura, K., Morrison, S. F. and Romanovsky, A. A. (2010) The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch14

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA

  2. 2

    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • role for TRPV1 in other physiological processes besides pain transmission;
  • TRPV1 channel in normal thermoregulation;
  • TRPV1 antagonists as novel drugs in pain management - implications for drug development

Summary

This chapter contains sections titled:

  • Introduction

  • How is deep Tb Regulated?

  • Distribution of TRPV1 Channels

  • TRPV1 Agonists

  • TRPV1 Antagonists

  • Genetic Approach

  • Implications for Drug Development

  • The Roles of TRPV1 Channels in Thermoregulation: Overall Conclusions

  • Note Added in Proof

  • Acknowledgments

  • References