15. The Role of TRPV1 in Respiratory Diseases

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Serena Materazzi1,
  2. Alain Tchoimou1,
  3. Romina Nassini1,
  4. Marcello Trevisani2,† and
  5. Pierangelo Geppetti1,2

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch15

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Materazzi, S., Tchoimou, A., Nassini, R., Trevisani, M. and Geppetti, P. (2010) The Role of TRPV1 in Respiratory Diseases, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch15

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

  2. 2

    Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy

  1. PharmEste srl, Ferrara, Italy

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • role of TRPV1 in respiratory diseases;
  • neurogenic inflammation and TRPV1 in models of airway diseases;
  • TRPV1 role in cough and rhinitis - possibility of intervention by blocking TRPV1 and TRPV1-expressing neurons

Summary

This chapter contains sections titled:

  • Primary Sensory Neurons and Neurogenic Inflammation in the Airways

  • Primary Sensory Neurons and Activation of Reflex Responses in the Airways

  • Neurogenic Inflammation and TRPV1 in Models of Airway Diseases

  • Localization and Plasticity of TRPV1 in the Airways

  • Sneezing, Cough, and TRPV1 Channel in Airway Diseases

  • Conclusions

  • Acknowledgments

  • References