16. The Role of TRPV1 in Diabetes

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Hubert Tsui1,
  2. Ruslan Dorfman2,
  3. Michael W. Salter1 and
  4. H.-michael Dosch1

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch16

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Tsui, H., Dorfman, R., Salter, M. W. and Dosch, H.-m. (2010) The Role of TRPV1 in Diabetes, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch16

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    University of Toronto, The Hospital For Sick Children, Research Institute, Neurosciences & Mental Health Programs, Toronto, Ontario, Canada

  2. 2

    University of Toronto, The Hospital For Sick Children, Research Institute, Genetics & Genome Biology Program, Toronto, Ontario, Canada

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • role of TRPV1 in diabetes;
  • islet endocrine function of TRPV1-positive sensory neurons;
  • role of TRPV1 in T1D pathogenesis - explaining autoimmune diabetes

Summary

This chapter contains sections titled:

  • Overview

  • A New Model of a Classic Disease Group

  • T1D

  • A Model of T1D Pathogenesis

  • Islet-Innervating Neurons

  • Sensory Neurons

  • Pancreatic Sensory Neurons

  • Islet Endocrine Function of TRPV1 - Positive Sensory Neurons

  • Effects of CGRP on Islet Function

  • Effects of SP on Islet Function

  • TRPV1 on β Cells

  • A Role for TRPV1 in Glucose Metabolism

  • Sensory Neurons and T1D

  • TRPV1 Mutations in the Nod Mouse

  • Lasting Reversal of Acute T1D by SP

  • Summary

  • References