2. Role of TRP Channels in Pain: An Overview

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Arpad Szallasi1,2

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch2

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Szallasi, A. (2010) Role of TRP Channels in Pain: An Overview, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch2

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    Departments of Pathology and Laboratory Medicine, Monmouth Medical Center, Long Branch, NJ, USA

  2. 2

    Drexel University College of Medicine, Philadelphia, PA, USA

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • role of TRP channels in pain;
  • emerging role of TRP channels in visceral pain;
  • targeting TRP channels on nociceptors - attractive new and logical strategy in drug development

Summary

This chapter contains sections titled:

  • Introduction

  • The Central Role of TRP Channels in Nociception and Inflammatory Pain

  • The Emerging Role of TRP Channels in Visceral Pain

  • Contribution of TRP Channels to Neuropathic Pain, Cancer Pain, and Migraine

  • Differential TRP Channel Expression Defines Functional Sensory Neuron Subtypes: Implications for Drug development

  • Taking a Short TR(i)P beyond Pain

  • Disease - Related Changes in TRP Channel Expression: a New Spin Complicating Drug Development

  • TRPS on Nociceptive Neurons as Targets for Novel Analgesic Drugs: Attractive but not so Innocent

  • Concluding Remarks

  • References