4. TRPV1 Genetics

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Ruslan Dorfman1,
  2. Hubert Tsui2,
  3. Michael W. Salter2 and
  4. H.-Michael Dosch2

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch4

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Dorfman, R., Tsui, H., Salter, M. W. and Dosch, H.-M. (2010) TRPV1 Genetics, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch4

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    University of Toronto, The Hospital For Sick Children, Research Institute, Genetics & Genome Biology Program, Toronto, Ontario, Canada

  2. 2

    University of Toronto, The Hospital For Sick Children, Research Institute, Neurosciences & Mental Health Programs, Toronto, Ontario, Canada

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • TRPV1 genetics;
  • functional TRPV1 differences in nonconserved amino acid positions;
  • functional polymorphisms in human trpv1 gene

Summary

This chapter contains sections titled:

  • Overview

  • trpv1 GENE STRUCTURE in different Species

  • Alternative Splicing of trpv1 Results in different Functional Variants

  • Functional TRPV1 differences in Nonconserved Amino Acid Positions

  • Structure – Function Analysis

  • Missense Mutations in Non-Obese Diabetic (NOD) Mice affect TRPV1 Function and Cause Diabetes

  • Functional Polymorphisms in the Human trpv1 Gene

  • Selection Pressure on Human trpv1 Gene?

  • Rare Variants of the Human trpv1 Gene

  • References