7. TRPV1 and Bone Cancer Pain

  1. Arthur Gomtsyan and
  2. Connie R. Faltynek
  1. Juan Miguel Jimenez-Andrade1 and
  2. Patrick Mantyh1,2

Published Online: 22 FEB 2010

DOI: 10.1002/9780470588284.ch7

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

How to Cite

Jimenez-Andrade, J. M. and Mantyh, P. (2010) TRPV1 and Bone Cancer Pain, in Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders (eds A. Gomtsyan and C. R. Faltynek), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588284.ch7

Editor Information

  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA

Author Information

  1. 1

    Department of Pharmacology, University of Arizona, Tucson, AZ, USA

  2. 2

    Research Service, VA Medical Center, Minneapolis, MN, USA

Publication History

  1. Published Online: 22 FEB 2010
  2. Published Print: 12 FEB 2010

ISBN Information

Print ISBN: 9780470175576

Online ISBN: 9780470588284

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Keywords:

  • TRPV1 and bone cancer pain;
  • expression of TRPV1 in sensory nerve fibers innervating the femur;
  • potential activators or modulators of TRPV1 in bone cancer

Summary

This chapter contains sections titled:

  • Introduction

  • The Challenge of Bone Cancer Pain

  • Skeletal Remodeling and Acidosis in Bone Cancer Pain

  • Expression of TRPV1 in Sensory Nerve Fibers that Innervate the Femur

  • TRPV1 Antagonist or Disruption of the TRPV1 Gene Attenuates Bone Cancer Pain - Related Behaviors

  • TRPV1 Antagonist Potentiates the Analgesic Efficacy of Morphine in the Bone Cancer Pain Model

  • Potential Activators or Modulators of TRPV1 in Bone Cancer

  • Summary

  • References