15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization

  1. Richard B. Cole
  1. Sonal Mathur1,
  2. Alexis Nazabal2 and
  3. Renato Zenobi3

Published Online: 27 NOV 2012

DOI: 10.1002/9780470588901.ch15

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition

How to Cite

Mathur, S., Nazabal, A. and Zenobi, R. (2010) Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization, in Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition (ed R. B. Cole), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588901.ch15

Author Information

  1. 1

    Max Planck Institute for Chemical Ecology, Jena, Germany

  2. 2

    CovalX AG, Zurich, Switzerland

  3. 3

    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland

Publication History

  1. Published Online: 27 NOV 2012
  2. Published Print: 9 APR 2010

ISBN Information

Print ISBN: 9780471741077

Online ISBN: 9780470588901

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Keywords:

  • noncovalent interactions;
  • optical spectroscopy;
  • surface plasmon resonance;
  • spray methods;
  • nonacidic matrices

Summary

This chapter contains sections titled:

  • Introduction

  • Detecting Noncovalent Complexes and Determining Their Kd by MALDI MS

  • Detecting Noncovalent Complexes and Determining their Kd values by ESI MS

  • Critical Discussion of MS-based Methods to Determine Dissociation Constants

  • Summary