2. Selectivity in Electrospray Ionization Mass Spectrometry

  1. Richard B. Cole
  1. Nadja B. Cech1 and
  2. Christie G. Enke2

Published Online: 27 NOV 2012

DOI: 10.1002/9780470588901.ch2

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition

How to Cite

Cech, N. B. and Enke, C. G. (2010) Selectivity in Electrospray Ionization Mass Spectrometry, in Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, Second Edition (ed R. B. Cole), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470588901.ch2

Author Information

  1. 1

    Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina

  2. 2

    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico

Publication History

  1. Published Online: 27 NOV 2012
  2. Published Print: 9 APR 2010

ISBN Information

Print ISBN: 9780471741077

Online ISBN: 9780470588901

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Keywords:

  • ion formation;
  • electrochemical oxidation;
  • signal suppression;
  • autoprotolysis;
  • surface activity

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanisms of Ion Formation

  • Ionic Composition of ESI Droplets

  • Excess Charge and Its Location

  • A Model for Competition and Saturation in Solution

  • Surface Activity as a Source of Selectivity

  • Competition and Signal Suppression

  • Gas-Phase Proton Transfer as a Source of Selectivity

  • Effects of Nebulization and Flow Rate

  • Differences between Positive and Negative Ion ESI-MS