1. BACE, APP Processing, and Signal Transduction in Alzheimer's Disease

  1. Varghese John
  1. Dale E. Bredesen MD1 and
  2. Edward H. Koo MD2

Published Online: 26 MAR 2010

DOI: 10.1002/9780470594087.ch1

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

How to Cite

Bredesen, D. E. and Koo, E. H. (2010) BACE, APP Processing, and Signal Transduction in Alzheimer's Disease, in BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease (ed V. John), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470594087.ch1

Editor Information

  1. Buck Institute for Age Research Novato, California, USA

Author Information

  1. 1

    Buck Institute for Age Research, Novato, CA; Department of Neurology, University of California, San Francisco, CA, USA

  2. 2

    Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA

Publication History

  1. Published Online: 26 MAR 2010
  2. Published Print: 11 FEB 2010

ISBN Information

Print ISBN: 9780470293423

Online ISBN: 9780470594087

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Keywords:

  • BACE, APP processing and signal transduction in Alzheimer's disease;
  • BACE cleavage, caspase cleavage and neuronal trophic dependence;
  • key mutations proximal of app processing to Aβ

Summary

This chapter contains sections titled:

  • Introduction

  • BACE Cleavage of APP as a Molecular Switching Mechanism

  • AD: An Imbalance in Cellular Dependence?

  • BACE Cleavage, Caspase Cleavage, and Neuronal Trophic Dependence

  • BACE Cleavage of APP, Dependence Receptors, and Alzheimer Pathology

  • Key Mutations Proximal of APP Processing to Aβ

  • Final Remarks

  • Acknowledgments

  • References