10. Future Strategies for Development of Novel BACE Inhibitors: Anti-APP β-Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease

  1. Varghese John
  1. Beka Solomon PhD1,
  2. Michal Arbel-Ornath PhD1,
  3. Clare Peters-Libeu PhD2 and
  4. Varghese John PhD2

Published Online: 26 MAR 2010

DOI: 10.1002/9780470594087.ch10

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

How to Cite

Solomon, B., Arbel-Ornath, M., Peters-Libeu, C. and John, V. (2010) Future Strategies for Development of Novel BACE Inhibitors: Anti-APP β-Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease, in BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease (ed V. John), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470594087.ch10

Editor Information

  1. Buck Institute for Age Research Novato, California, USA

Author Information

  1. 1

    Department of Molecular Microbiology & Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel

  2. 2

    Buck Institute for Age Research Novato, California, USA

Publication History

  1. Published Online: 26 MAR 2010
  2. Published Print: 11 FEB 2010

ISBN Information

Print ISBN: 9780470293423

Online ISBN: 9780470594087

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Keywords:

  • Alzheimer's disease (AD), progressive neurodegeneration - dementia in elderly;
  • anti β-site antibody mediating inhibition of Aβ production via endocytic pathway;
  • limiting intracellular Aβ formation - at early stages of AD development

Summary

This chapter contains sections titled:

  • Introduction

  • β-Secretase: Discovery, Function, and Inhibitors

  • Generation of Aβ Peptides via the Endocytic Pathway

  • Generation of Anti-APP β-Site Antibodies

  • Antibody Interference with Aβ Production in Cellular Model

  • Antibody Interference with Aβ Production in Animal Models

  • Identification of APP Binding Small Molecules that Block β-Site Cleavage of APP

  • Final Remarks

  • Acknowledgments

  • References