2. Identification of BACE as a Target in Alzheimer's Disease

  1. Varghese John
  1. Robert L. Heinrikson PhD1 and
  2. Sukanto Sinha PhD2

Published Online: 26 MAR 2010

DOI: 10.1002/9780470594087.ch2

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

How to Cite

Heinrikson, R. L. and Sinha, S. (2010) Identification of BACE as a Target in Alzheimer's Disease, in BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease (ed V. John), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470594087.ch2

Editor Information

  1. Buck Institute for Age Research Novato, California, USA

Author Information

  1. 1

    Proteos, Inc., Kalamazoo, MI, USA

  2. 2

    Active Site Pharmaceuticals, Inc., Berkeley, CA, USA

Publication History

  1. Published Online: 26 MAR 2010
  2. Published Print: 11 FEB 2010

ISBN Information

Print ISBN: 9780470293423

Online ISBN: 9780470594087

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Keywords:

  • BACE identification - as target in Alzheimer's disease;
  • β-site APP cleaving enzyme (BACE) or β-secretase;
  • BACE target validation

Summary

This chapter contains sections titled:

  • Introduction

  • The Search for β-Secretase

  • Validation of the BACE Target

  • Final Remarks

  • References