5. Fragment-Based Approaches for Identification of BACE Inhibitors

  1. Varghese John
  1. Andreas Kuglstatter PhD1 and
  2. Michael Hennig PhD2

Published Online: 26 MAR 2010

DOI: 10.1002/9780470594087.ch5

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

How to Cite

Kuglstatter, A. and Hennig, M. (2010) Fragment-Based Approaches for Identification of BACE Inhibitors, in BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease (ed V. John), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470594087.ch5

Editor Information

  1. Buck Institute for Age Research Novato, California, USA

Author Information

  1. 1

    Roche Palo Alto LLC, Palo Alto, CA, USA

  2. 2

    F. Hoffmann-La Roche Ltd, Basel, Switzerland

Publication History

  1. Published Online: 26 MAR 2010
  2. Published Print: 11 FEB 2010

ISBN Information

Print ISBN: 9780470293423

Online ISBN: 9780470594087

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Keywords:

  • fragment-based approaches for BACE inhibitor identification;
  • biophysical methods applied to BACE fragment screens;
  • BACE inhibitors identified by fragment screening

Summary

This chapter contains sections titled:

  • Introduction

  • Biophysical Methods Applied to BACE Fragment Screens

  • BACE Inhibitors Identified by Fragment Screening

  • Final Remarks

  • References