6. Structure-Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3-Dimensional Structure, and Computational Analysis

  1. Varghese John
  1. Felix F. Vajdos PhD1,
  2. Veerabahu Shanmugasundaram PhD1 and
  3. Alfredo G. Tomasselli PhD2

Published Online: 26 MAR 2010

DOI: 10.1002/9780470594087.ch6

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

How to Cite

Vajdos, F. F., Shanmugasundaram, V. and Tomasselli, A. G. (2010) Structure-Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3-Dimensional Structure, and Computational Analysis, in BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease (ed V. John), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470594087.ch6

Editor Information

  1. Buck Institute for Age Research Novato, California, USA

Author Information

  1. 1

    Pfizer Global Research and Development, Groton, CT, USA

  2. 2

    Pfizer Inc., Saint Louis, MO, USA

Publication History

  1. Published Online: 26 MAR 2010
  2. Published Print: 11 FEB 2010

ISBN Information

Print ISBN: 9780470293423

Online ISBN: 9780470594087

SEARCH

Keywords:

  • structure-based design of BACE inhibitors - technical and practical aspects of preparation;
  • BACE inhibitors - peptidomimetics and nonpeptidomimetics;
  • computational methods - role in drug discovery research

Summary

This chapter contains sections titled:

  • Introduction

  • Preparation of BACE for Structural Studies

  • Crystallographic Studies of BACE

  • Structural Studies with BACE Inhibitors: Peptidomimetics and Nonpeptidomimetics

  • Computational Approaches

  • Final Remarks

  • Acknowledgment

  • References