4. Design Adaptations Part Two: Additional Design Changes

  1. Michael J. Rosenberg

Published Online: 23 FEB 2010

DOI: 10.1002/9780470599686.ch4

The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development

The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development

How to Cite

Rosenberg, M. J. (2010) Design Adaptations Part Two: Additional Design Changes, in The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470599686.ch4

Publication History

  1. Published Online: 23 FEB 2010
  2. Published Print: 25 JAN 2010

ISBN Information

Print ISBN: 9780470247518

Online ISBN: 9780470599686

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Keywords:

  • design adaptations;
  • additional design changes;
  • sample-size reestimation;
  • adaptive randomization;
  • biomarker adaptive

Summary

This chapter contains sections titled:

  • Sample-Size Reestimation

  • Seamless Designs: Combining Multiple Phases

  • Adaptive Randomization

  • Other Types of Design Adaptations

  • Conclusions