Facilitating Reliability and Traceability of Measurement Results in Laboratory Medicine by Certified Reference Materials

  1. French College of Metrology
  1. B. Toussaint,
  2. H. Schimmel and
  3. H. Emons

Published Online: 3 FEB 2010

DOI: 10.1002/9780470611371.ch19

Transverse Disciplines in Metrology

Transverse Disciplines in Metrology

How to Cite

French College of Metrology (2009) Facilitating Reliability and Traceability of Measurement Results in Laboratory Medicine by Certified Reference Materials, in Transverse Disciplines in Metrology, ISTE, London, UK. doi: 10.1002/9780470611371.ch19

Author Information

  1. Institute for Reference Materials and Measurements, Joint Research Centre, European Commission (EC-JRC-IRMM), Retieseweg 111, 2440 Geel, Belgium

Publication History

  1. Published Online: 3 FEB 2010
  2. Published Print: 1 JAN 2009

ISBN Information

Print ISBN: 9781848210486

Online ISBN: 9780470611371

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Keywords:

  • metrological traceability;
  • reference materials;
  • matrix materials;
  • commutability study;
  • mass fraction

Summary

Comparability of results from different analytical procedures and commercial diagnostic kits is a key issue in laboratory medicine. In order to achieve this, reference procedures and Certified Reference Materials (CRMs) as well as quality control materials are required. In this presentation, the crucial aspects of the development and certification of CRMs will be described and illustrated by recent examples. In particular, establishing the metrological traceability of pure substance CRMs, developing matrix CRMs and investigating the commutability of these materials will be discussed. Finally, a distinction will also be made between Quality Control Materials and Certified Reference Materials in the way they facilitate reliability and traceability of measurement results.