5. Myths and Realities of Gene Duplication

  1. Katharina Dittmar2 and
  2. David Liberles3
  1. Austin L. Hughes and
  2. Robert Friedman

Published Online: 14 MAR 2011

DOI: 10.1002/9780470619902.ch5

Evolution after Gene Duplication

Evolution after Gene Duplication

How to Cite

Hughes, A. L. and Friedman, R. (2010) Myths and Realities of Gene Duplication, in Evolution after Gene Duplication (eds K. Dittmar and D. Liberles), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470619902.ch5

Editor Information

  1. 2

    Department of Biological Sciences, SUNY at Buffalo, Buffalo, New York, USA

  2. 3

    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, USA

Author Information

  1. Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA

Publication History

  1. Published Online: 14 MAR 2011
  2. Published Print: 20 SEP 2010

ISBN Information

Print ISBN: 9780470593820

Online ISBN: 9780470619902



  • myths and realities of gene duplication - theoretical ideas proposed regarding evolution of new gene and protein function after gene duplication;
  • duplication–degeneration–complementation (DDC) - complementary loss of function in two duplicates;
  • segmental duplication and its aftermath - polyploidization obsession, Susumo Ohno's belief of duplication of entire genomes by polyploidization, key to origin of new adaptations


This chapter contains sections titled:

  • Introduction

  • Hypotheses of New Gene Function

  • Role of Natural Selection

  • Expression Differentiation

  • Segmental Duplication and its Aftermath

  • Duplicate Genes in Networks

  • Conclusions

  • References