Chapter 11. In Vitro Genotox Assays

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. David Kirkland1,2 and
  2. David Gatehouse3

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch11

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Kirkland, D. and Gatehouse, D. (2010) In Vitro Genotox Assays, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch11

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. 1

    University of Wales, Swansea, United Kingdom

  2. 2

    Tadcaster, North Yorkshire, United Kingdom

  3. 3

    Buntingford, Hertfordshire, United Kingdom

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728

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Keywords:

  • in vitro genotox assays and In Vitro Metabolic Activation;
  • In Vitro Tests for Gene Mutation in Mammalian Cells;
  • The In Vitro Micronucleus Test and In Vitro Comet Assay

Summary

This chapter contains sections titled:

  • Introduction

  • In Vitro Metabolic Activation

  • In Vitro Tests for Gene Mutation in Bacteria

  • In Vitro Tests for Gene Mutation in Mammalian Cells

  • In Vitro Tests for Chromosome Damage in Mammalian Cells

  • The In Vitro Micronucleus Test

  • In Vitro Test for Unscheduled DNA Synthesis in Rat Hepatocytes

  • In Vitro Comet Assay

  • Strengths and Limitations

  • References