Chapter 12. In Vivo Genotoxicity Assays

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. Véronique Thybaud

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch12

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Thybaud, V. (2010) In Vivo Genotoxicity Assays, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch12

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. Disposition-Safety and Animal Research, Preclinical Safety, Sanofi Aventis, Vitry sur Seine, France

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728



  • in vivo genotoxicity assays;
  • in vivo genotoxicity assays - in standard battery of tests;
  • in vivo genotoxicity assays used - as complementary or follow-up tests, comet assay and gene mutation assays


This chapter contains sections titled:

  • Introduction

  • Parameters and Criteria for Valid In Vivo Genotoxicity Assays and Implications for Experimental Design

  • In Vivo Genotoxicity Assays Required in the Standard Battery of Tests

  • In Vivo Genotoxicity Assays Used Mainly as Complementary or Follow-Up Tests

  • Conclusion and Perspectives

  • References