Chapter 13. Framework Analysis for Determining Mode of Action and Human Relevance

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. R. Julian Preston

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch13

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Preston, R. J. (2010) Framework Analysis for Determining Mode of Action and Human Relevance, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch13

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728



  • human relevance assessment - of chemical-induced tumors;
  • framework analysis for determining mode of action and human relevance;
  • framework for analyzing mode of action (MOA) - establishing and applying key events in support of MOA


This chapter contains sections titled:

  • Introduction

  • Framework Analysis: Mode of Action and Key Events

  • Framework Analysis: Human Relevance

  • Future Directions

  • References