Chapter 17. Mode of Action Analysis and Human Relevance of Liver Tumors Induced by PPARα Activation

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. J. Christopher Corton

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch17

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Corton, J. C. (2010) Mode of Action Analysis and Human Relevance of Liver Tumors Induced by PPARα Activation, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch17

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728



  • mode of action analysis and human relevance of liver tumors - induced by PPARα activation;
  • central role PPARα plays - in mediating pleiotropic effects of exposure;
  • PPARα expression, cited for determining species-specific differences in PPARα activator responsiveness


This chapter contains sections titled:

  • Overview

  • Introduction

  • Mode of Action Analysis in the EPA Risk Assessment Framework

  • Relevance of PPARα Activator-Induced Rodent Liver Tumor Response to Humans

  • References