Chapter 18. Alpha2U-Globulin Nephropathy and Chronic Progressive Nephropathy as Modes of Action for Renal Tubule Tumor Induction in Rats, and Their Possible Interaction

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. Edward A. Lock1 and
  2. Gordon C. Hard2

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch18

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Lock, E. A. and Hard, G. C. (2010) Alpha2U-Globulin Nephropathy and Chronic Progressive Nephropathy as Modes of Action for Renal Tubule Tumor Induction in Rats, and Their Possible Interaction, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch18

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. 1

    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom

  2. 2

    Independent Consultant, Tairua, New Zealand

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728

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Keywords:

  • protein, α2u-globulin (α2u-g), lower concentrations in female rats, and not at all in mice;
  • chemicals, increasing incidence of renal tubule tumors;
  • α2u-g nephropathy and CPN - linked from early time-point in development

Summary

This chapter contains sections titled:

  • Introduction

  • Chemicals that Increase the Incidence of Renal Tubule Tumors in Male Rats by an α2u-Globulin Mode of Action

  • Chemicals Increasing the Incidence of Renal Tumors Through Exacerbation of Spontaneous Chronic Progressive Nephropathy (CPN)

  • Chemicals Increasing RTT Incidence Through a Mode of Action Involving Exacerbation of CPN

  • Examples Where the α2u-Globulin and Exacerbated CPN Modes of Action May Be Acting in Concert

  • Relevance of Rat α2u-Globulin Nephropathy and CPN to Humans

  • References