Chapter 25. Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. Rafael Meza1,
  2. Jihyoun Jeon2 and
  3. Suresh H. Moolgavkar3

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch25

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Meza, R., Jeon, J. and Moolgavkar, S. H. (2010) Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch25

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. 1

    Division of Mathematical Modeling, University of British Columbia Centre for Disease Control, Vancouver, British Columia, Canada

  2. 2

    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seatte, Washington, USA

  3. 3

    Center for Epidemiology, Biostatistics, and Computational Biology, Exponent, Inc., Bellevue, Washington, USA

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728



  • quantitative risk assessment of nongenotoxic carcinogens - and two-stage clonal expansion (TSCE) model, capturing initiation–promotion–conversion paradigm in carcinogenesis;
  • “mutation rate” of malignant compartment - as rate of cancer detection or death;
  • lung cancer incidence in Chinese Tin Miners (CTM) cohort - effects of radon exposure on promotion and malignant conversion rates


This chapter contains sections titled:

  • Introduction

  • Some Examples and Applications

  • Concluding Remarks

  • References