Chapter 28. Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies

  1. Ching-Hung Hsu and
  2. Todd Stedeford
  1. Amy E. Brix1,
  2. Jerry F. Hardisty1 and
  3. Ernest E. McConnell2

Published Online: 5 AUG 2010

DOI: 10.1002/9780470622728.ch28

Cancer Risk Assessment

Cancer Risk Assessment

How to Cite

Brix, A. E., Hardisty, J. F. and McConnell, E. E. (2010) Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies, in Cancer Risk Assessment (eds C.-H. Hsu and T. Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470622728.ch28

Editor Information

  1. Health, Safety & Environment, Albemarle Corporation, Baton Rouge, Louisiana, USA

Author Information

  1. 1

    Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA

  2. 2

    Tox Path, Inc., Raleigh, North Carolina, USA

Publication History

  1. Published Online: 5 AUG 2010
  2. Published Print: 6 JUL 2010

ISBN Information

Print ISBN: 9780470238226

Online ISBN: 9780470622728



  • combining neoplasms - for evaluation of rodent carcinogenesis studies;
  • differentiating benign and malignant neoplasms - evidence for aggressiveness of neoplasm type;
  • rationale, criteria, and guidelines for combining neoplasms - at the same time and in different sites in long-term toxicology


This chapter contains sections titled:

  • Introduction

  • Rationale for Combining Neoplasms

  • Usefulness of Differentiating Benign from Malignant Neoplasms and of Subclassifying Neoplasms

  • Criteria for Combining Neoplasms

  • Summary

  • References