Chapter 2. Chapter 2. Signal Transduction Cascades Controlling Osteoblast Differentiation

  1. ASBMR
  1. Carola Krause1,
  2. David J. J. de Gorter1,
  3. Marcel Karperien2 and
  4. Peter ten Dijke1

Published Online: 23 DEC 2009

DOI: 10.1002/9780470623992.ch2

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

How to Cite

ASBMR (2008) Chapter 2. Signal Transduction Cascades Controlling Osteoblast Differentiation, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch2

Author Information

  1. 1

    Department of Molecular Cell Biology, University Medical Centre, Leiden, The Netherlands

  2. 2

    Department of Tissue Regeneration, University of Twente/Fuculty Science and Technology Institute for Biomedical Technology, Enschede, The Netherlands

Publication History

  1. Published Online: 23 DEC 2009
  2. Published Print: 18 NOV 2008

ISBN Information

Print ISBN: 9780977888214

Online ISBN: 9780470623992

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Keywords:

  • osteoblast;
  • bone formation;
  • WNT;
  • bone morphogenetic protein;
  • Hedgehog;
  • PTH;
  • PTH-related peptide;
  • TGF-β;
  • fibroblast growth factor: IGF;
  • Notch;
  • Runx2;
  • Osterix; nuclear factor for activated T cells;
  • β-catenin;
  • Smad

Summary

This chapter contains sections titled:

  • Introduction

  • Runx2 and Osterix Transcription Factors

  • BMP Signaling

  • TGF-β Signaling

  • WNT Signaling

  • Hedgehog Signaling

  • PTH Signaling

  • IGF-1 Signaling

  • FGF Signaling

  • Notch Signaling

  • Concluding Remarks

  • Acknowledgments