Chapter 8. Chapter 8. Animal Models: Genetic Manipulation

  1. ASBMR
  1. Karen Lyons

Published Online: 23 DEC 2009

DOI: 10.1002/9780470623992.ch8

Book Title

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Additional Information

How to Cite

ASBMR (2009) Chapter 8. Animal Models: Genetic Manipulation, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch8

Publication History

  1. Published Online: 23 DEC 2009
  2. Published Print: 18 NOV 2008

ISBN Information

Print ISBN: 9780977888214

Online ISBN: 9780470623992

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CHAPTER TOOLS

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Keywords:

  • knockout;
  • transgenic;
  • embryonic stem cells;
  • gene targeting

Summary

This chapter contains sections titled:

  • Introduction

  • Overexpression of Target Genes

  • Gene Targeting

  • Tissue-Specific and Inducible Knockouts to Study Skeletal Biology

  • Knock-In Models

  • Lineage Tracing and Activity Reporters

  • Functional Genomics

  • General Considerations

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