Chapter 14. The Application of Cationic Antimicrobial Peptides in Cancer Treatment: Laboratory Investigations and Clinical Potential

  1. Arsénio M. Fialho3 and
  2. Ananda M. Chakrabarty4
  1. Ashley L. Hilchie1 and
  2. David W. Hoskin2

Published Online: 18 AUG 2010

DOI: 10.1002/9780470626528.ch14

Emerging Cancer Therapy

Emerging Cancer Therapy

How to Cite

Hilchie, A. L. and Hoskin, D. W. (2010) The Application of Cationic Antimicrobial Peptides in Cancer Treatment: Laboratory Investigations and Clinical Potential, in Emerging Cancer Therapy (eds A. M. Fialho and A. M. Chakrabarty), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470626528.ch14

Editor Information

  1. 3

    Institute for Biotechnology and Bioengineering (IBB), Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal

  2. 4

    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA

Author Information

  1. 1

    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

  2. 2

    Departments of Microbiology and Immunology, and Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

Publication History

  1. Published Online: 18 AUG 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470444672

Online ISBN: 9780470626528

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Keywords:

  • cationic antimicrobial peptide application - in cancer treatment laboratory investigations and clinical potential;
  • arginine-glycine-aspartic acid (RGD) - receptor recognition sequence allowing adhesion molecules;
  • enhancing anticancer activity and cap stability - through peptide modification

Summary

This chapter contains sections titled:

  • Introduction

  • Molecular basis for Cancer Cell Targeting by CAPs

  • Mechanisms of Cancer Cell Killing by CAPs

  • Modulation of Immune Function by CAPs

  • Preclinical and Clinical Investigations

  • Enhancing Anticancer Activity and Cap Stability through Peptide Modification

  • Conclusion

  • References