Chapter 15. Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents

  1. Arsénio M. Fialho3 and
  2. Ananda M. Chakrabarty4
  1. Neil R. Williamson1,
  2. Suresh Chawrai2,
  3. Finian J. Leeper2 and
  4. George P. C. Salmond1

Published Online: 18 AUG 2010

DOI: 10.1002/9780470626528.ch15

Emerging Cancer Therapy

Emerging Cancer Therapy

How to Cite

Williamson, N. R., Chawrai, S., Leeper, F. J. and Salmond, G. P. C. (2010) Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents, in Emerging Cancer Therapy (eds A. M. Fialho and A. M. Chakrabarty), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470626528.ch15

Editor Information

  1. 3

    Institute for Biotechnology and Bioengineering (IBB), Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal

  2. 4

    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA

Author Information

  1. 1

    Department of Biochemistry, University of Cambridge, Cambridge, UK

  2. 2

    Department of Chemistry, University of Cambridge, Cambridge, UK

Publication History

  1. Published Online: 18 AUG 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470444672

Online ISBN: 9780470626528



  • prodiginines, and their potential utility - as proapoptotic anticancer agents;
  • mutasynthesis to generate novel prodiginines;
  • bioactive prodiginines - displaying anticancer activity


This chapter contains sections titled:

  • Introduction

  • History of Prodiginines

  • Biosynthesis of Prodiginines

  • Mutasynthesis to Generate Novel Prodiginines

  • The Bioactive Prodiginines Display Anticancer Activity

  • Structure–Activity Relationship Studies of Bacterial Prodiginines

  • Prodiginines Mediate Copper-Dependent DNA Cleavage

  • Prodiginines as H+/CL Symporters and a Role in Intracellular Acidification

  • Signal Transduction and Mapks

  • Cell Cycle Inhibition

  • Case Study

  • Summary

  • References