Chapter 4. Live Clostridia: A Powerful Tool in Tumor Biotherapy

  1. Arsénio M. Fialho3 and
  2. Ananda M. Chakrabarty4
  1. Lieve Van Mellaert1,
  2. Ming Q Wei2 and
  3. Jozef Anné1

Published Online: 18 AUG 2010

DOI: 10.1002/9780470626528.ch4

Emerging Cancer Therapy

Emerging Cancer Therapy

How to Cite

Van Mellaert, L., Wei, M. Q. and Anné, J. (2010) Live Clostridia: A Powerful Tool in Tumor Biotherapy, in Emerging Cancer Therapy (eds A. M. Fialho and A. M. Chakrabarty), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470626528.ch4

Editor Information

  1. 3

    Institute for Biotechnology and Bioengineering (IBB), Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal

  2. 4

    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA

Author Information

  1. 1

    Laboratory of Bacteriology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

  2. 2

    Division of Molecular and Gene Therapies, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Queensland, Australia

Publication History

  1. Published Online: 18 AUG 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470444672

Online ISBN: 9780470626528



  • live clostridia - powerful tools in tumor biotherapy;
  • C.NOVYI-NT - revival of native oncolytic clostridia for biotherapy purposes;
  • C.Perfringens modulation - to an oncotherapeutic microbe


This chapter contains sections titled:

  • The Genus Clostridium in a Nutshell

  • The Tumor Microenvironment: Resistant to Conventional Tumor Therapeutics but a Haven for Clostridia

  • The First ERA of Tumor Biotherapy using Clostridium Spores

  • Recombinant Clostridia as Tool in Tumor Biotherapy

  • C. NOVYI-NT: The Revival of Native Oncolytic Clostridia for Biotherapy Purposes

  • Modulation of C. Perfringens to an Oncotherapeutic Microbe

  • Cdat: Clostridium-Directed Antibody Therapy

  • Advantages of Clostridial Spores as Antitumor Tools

  • Further Improvements and Future Perspectives

  • References