Chapter 9. Arginine Deiminase and Cancer Therapy

  1. Arsénio M. Fialho3 and
  2. Ananda M. Chakrabarty4
  1. Lynn Feun1,
  2. M. Tien Kuo2,
  3. Ming You1,
  4. Chung Jing Wu1,
  5. Medhi Wangpaichitr1 and
  6. Niramol Savaraj1

Published Online: 18 AUG 2010

DOI: 10.1002/9780470626528.ch9

Emerging Cancer Therapy

Emerging Cancer Therapy

How to Cite

Feun, L., Kuo, M. T., You, M., Wu, C. J., Wangpaichitr, M. and Savaraj, N. (2010) Arginine Deiminase and Cancer Therapy, in Emerging Cancer Therapy (eds A. M. Fialho and A. M. Chakrabarty), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470626528.ch9

Editor Information

  1. 3

    Institute for Biotechnology and Bioengineering (IBB), Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal

  2. 4

    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA

Author Information

  1. 1

    Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA

  2. 2

    Molecular Pathology, M.D. Anderson Cancer Center, Houston, TX, USA

Publication History

  1. Published Online: 18 AUG 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470444672

Online ISBN: 9780470626528



  • arginine deiminase and cancer therapy;
  • arginine deiminase mechanism of action of - selective starvation in tumor cells auxotrophic for arginine;
  • arginine deiminase - as an antitumor agent for malignant melanoma and hepatocellular carcinoma


This chapter contains sections titled:

  • Introduction

  • Clinical Studies

  • Mechanisms of Action

  • ASS Expression

  • Future Directions

  • References