8. Drug Discovery and Development by Combinatorial Biosynthesis

  1. Wu-Kuang Yeh3,
  2. Hsiu-Chiung Yang4 and
  3. James R. McCarthy5
  1. Matthew A. DeSieno1,
  2. Carl A. Denard1 and
  3. Huimin Zhao1,2

Published Online: 25 MAY 2011

DOI: 10.1002/9780470627303.ch8

Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis

Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis

How to Cite

DeSieno, M. A., Denard, C. A. and Zhao, H. (2010) Drug Discovery and Development by Combinatorial Biosynthesis, in Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis (eds W.-K. Yeh, H.-C. Yang and J. R. McCarthy), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470627303.ch8

Editor Information

  1. 3

    PreClinOmics, Inc., Indianapolis, Indiana, USA

  2. 4

    Eli Lilly and Company, Indianapolis, Indiana, USA

  3. 5

    Indiana University–Purdue University, Indianapolis, Indiana, USA

Author Information

  1. 1

    Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

  2. 2

    Departments of Chemistry, Biochemistry, and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Publication History

  1. Published Online: 25 MAY 2011
  2. Published Print: 13 SEP 2010

ISBN Information

Print ISBN: 9780470286241

Online ISBN: 9780470627303

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Keywords:

  • biosynthetic applications, in drug discovery and development by combinatorial biosynthesis - natural products, key source of therapeutic agents in pharmaceutical industry;
  • critical tool in combinatorial biosynthesis - utilization of heterologous hosts for production of original natural products and those modified;
  • combinatorial biosynthesis, time-consuming and labor-intensive process - methods and tools in combinatorial biosynthesis, microbiology techniques being far superior

Summary

This chapter contains sections titled:

  • Introduction

  • Tools for Combinatorial Biosynthesis

  • Examples of Combinatorial Biosynthesis

  • Conclusions and Future Prospects

  • References