Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Acyloin Rearrangement. Comprehensive Organic Name Reactions and Reagents. 5:18–20.
- Published Online: 15 SEP 2010
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Symmetrical α-hydroxy ketones, the aliphatic analogs of benzoins, is known as acyloins. In acyloin rearrangement, the α-hydroxycarbonyl compound is converted into its structural isomer (also an α-hydroxylcarbonyl compound), which is accomplished by the interchange of the carbonyl group and migration of an alkyl group to the adjacent carbon atom. This arrangement is promoted by acid or base and also under pyrolitic conditions. Thermal thermal acyloin rearrangement is also reported to accelerate in presence of high pressure. Acyloin rearrangement has general applications in organic synthesis.
- structural isomer;
- α-hydroxylcarbonyl compound;
- potassium superoxide