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Algar-Flynn-Oyamada (AFO) Reaction

(Algar-Flynn-Oyamada Oxidation)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr013

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Algar-Flynn-Oyamada (AFO) Reaction. Comprehensive Organic Name Reactions and Reagents. 13:52–56.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

Flavones have been reported to be synthesized via oxidative cyclization of 2′-oxychalcones with hydrogen peroxide under alkaline conditions. This reaction is generally known as the Algar-Flynn-Oyamada reaction. A variety of 2-hydroxychalcones with methoxy groups in different positions in the two aromatic nuclei smoothly undergo the AFO oxidation. This reaction has also been modified to convert 2′-hydroxychalcones into flavones via SeO2 oxidation. This reaction has wide application for preparation of flavones and flavonols.

Keywords:

  • flavones;
  • 2′-hydroxychalcones;
  • benzalcoumaranone;
  • SeO2 oxidation