Algar-Flynn-Oyamada (AFO) Reaction
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Algar-Flynn-Oyamada (AFO) Reaction. Comprehensive Organic Name Reactions and Reagents. 13:52–56.
- Published Online: 15 SEP 2010
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Flavones have been reported to be synthesized via oxidative cyclization of 2′-oxychalcones with hydrogen peroxide under alkaline conditions. This reaction is generally known as the Algar-Flynn-Oyamada reaction. A variety of 2-hydroxychalcones with methoxy groups in different positions in the two aromatic nuclei smoothly undergo the AFO oxidation. This reaction has also been modified to convert 2′-hydroxychalcones into flavones via SeO2 oxidation. This reaction has wide application for preparation of flavones and flavonols.
- SeO2 oxidation