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Alkene Metathesis

(Olefin Metathesis)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr014

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Alkene Metathesis. Comprehensive Organic Name Reactions and Reagents. 14:57–63.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

It has been found that the alkene metathesis (olefin metathesis) proceeds via insertion (or oxidative addition) followed by reductive elimination to afford the final product in the presence of only a catalytic amount of the Grubbs catalyst. Various types of ruthenium-based metallo-carbene complexes have been designed during the development of alkene metathesis. This general reaction can be divided into different subgroups based on the nature of alkene metathesis. A more cost-effective method for alkene metathesis is to generate the metallo-carbene in situ, which has a great industrial importance. Alkene metathesis is a synthetically powerful chemical transformation, enabling the synthesis of complicated molecular structures for the preparation of novel pharmaceuticals. This method has been applied to various studies for example, drug discovery, peptide synthesis, etc.

Keywords:

  • alkene metathesis;
  • cross-metathesis;
  • oxidative addition;
  • lactone (-)-gloeosporone