Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Appel Reaction. Comprehensive Organic Name Reactions and Reagents. 22:95–99.
- Published Online: 15 SEP 2010
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It has been reported that primary and secondary alcohols are transformed into corresponding chlorides with a significant tendency of inversion of the configuration when the alcohols react with triphenylphosphine and carbon tetrachloride. This reaction is known as Appel reaction and the mixture of triphenylphosphine and carbon tetrachloride is referred to as the Appel reagent and Appel agent. It has been found that triphenyl phosphine attacks the chlorine atom in carbon tetrachloride instead of the carbon atom in a traditional SN2 substitution. This reaction has general applications for the preparation of alkyl chlorides.
- carbon tetrachloride;
- SN2 substitution);
- alkyl chlorides