Arens-van Dorp Reaction
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Arens-van Dorp Reaction. Comprehensive Organic Name Reactions and Reagents. 23:100–102.
- Published Online: 15 SEP 2010
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α,β-unsaturated aldehydes are synthesized from the reaction of ethoxyethynemagnesium bromide and ketone or aldehyde. This reaction is referred to as the Arens and van Dorp reaction. Various modifications have been studied in this reaction and lithium ethoxyacetylene is generated by treatment of β-chlorovinyl ether with lithium amide, which then reacts with a ketone or aldehyde to form α,β-unsaturated aldehyde. The new protocol of this reaction is known as the Isler modification.
- ethoxyethynemagnesium bromide;
- β-chlorovinyl ether;
- chiral catalyst (BINOL);
- α,β-unsaturated aldehyde