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Arndt-Eistert Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr024

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Arndt-Eistert Synthesis. Comprehensive Organic Name Reactions and Reagents. 24:103–106.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The extension of carboxylic acid by one CH2 unit via the reaction of acyl chloride with diazomethane is referred to as the Arndt–Eistert synthesis. This reaction has been modified using other reagents than diazomethane to elongate the carboxylic acid chain. This reaction has application to synthesize unsaturated diazoketone and amino acids. Other early applications of such reactions are to prepare the carboxylic acids.

Keywords:

  • acyl chloride;
  • diazomethane;
  • carboxylic acids;
  • unsaturated diazoketone