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Baeyer-Drewson Reaction

(Baeyer-Drewson Indigo Synthesis)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr032

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Baeyer-Drewson Reaction. Comprehensive Organic Name Reactions and Reagents. 32:136–139.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

Indigo is obtained from the vegetable kingdom and is known as one of the oldest and most important coloring agents. The first protocol to synthesize indigos was developed by von Baeyer via the condensation of 2-nitrobenzaldehyde with acetone in the presence of dilute NaOH or Na2CO3. Hence, this reaction is known as the Baeyer–Drewson reaction. This reaction is very useful for the synthesis of indigo derivatives and also it can be utilized for testing the presence of methyl ketones. The Baeyer–Drewsen indigo synthesis in combination with the Lieben iodoform reaction has been developed to differentiate methylcarbinols from methyl ketones.

Keywords:

  • 2-nitrobenzaldehyde;
  • methylcarbonols;
  • iodoform reaction;
  • methyl ketones