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Baeyer Oxindole Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr034

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Baeyer Oxindole Synthesis. Comprehensive Organic Name Reactions and Reagents. 34:144–146.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

Oxindole is synthesized via the acidic reduction of o-nitrophenylacetic acid by tin and the subsequent cyclization of the resulting reduced intermediate. This reaction is known as Baeyer oxindole synthesis. Several other acidic reducing combinations can also be applied to preparation of oxindole.

Keywords:

  • o-nitrophenylacetic acid;
  • oxindole;
  • palladium catalyst;
  • cyclization