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Camps Reaction

(Camps Quinoline Synthesis)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr131

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Camps Reaction. Comprehensive Organic Name Reactions and Reagents. 131:598–601.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The formation of hydroxyquinolines by means of the treatment of N-acyl o-acylanilines with a base in alcohol solution is generally known as the Camps reaction. It has been reported that in this reaction, a variety of substituents can be introduced into position 3 and 4; and o-amino derivatives of acetophenone, benzophenone, benzoylacetic ester, benzoylcarbinol, propiophenone, etc. all undergo this reaction. However, when an electron-withdrawing group exists on the methylene group, only one product forms. This reaction has an importance to synthesize 3- and 4-substituted quinolines.

Keywords:

  • 2-hydroxy-3-cyano-4-methylquinoline;
  • o-amino acetophenone;
  • 2,3-cyclopentenoindole;
  • tetrahydrophenanthridone