(Camps Quinoline Synthesis)
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Camps Reaction. Comprehensive Organic Name Reactions and Reagents. 131:598–601.
- Published Online: 15 SEP 2010
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The formation of hydroxyquinolines by means of the treatment of N-acyl o-acylanilines with a base in alcohol solution is generally known as the Camps reaction. It has been reported that in this reaction, a variety of substituents can be introduced into position 3 and 4; and o-amino derivatives of acetophenone, benzophenone, benzoylacetic ester, benzoylcarbinol, propiophenone, etc. all undergo this reaction. However, when an electron-withdrawing group exists on the methylene group, only one product forms. This reaction has an importance to synthesize 3- and 4-substituted quinolines.
- o-amino acetophenone;