(Stephens-Castro Coupling, Castro Coupling)
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Castro-Stephens Coupling. Comprehensive Organic Name Reactions and Reagents. 136:619–623.
- Published Online: 15 SEP 2010
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The preparation of arylacetylenes by the coupling of cuprous acetylides with aryl halides in boiling pyridines is generally known as the Castro–Stephens coupling. Currently, this coupling is one of the most commonly used methods for the synthesis of aryl acetylenes. Moreover, under the Castro-Stephens coupling condition, acetylenes also couple with vinyl halides or even allyl halides and amines, by which indoles are formed in the coupling with amines.
- aryl halides;
- aryl acetylenes;
- vinyl halide;
- cuprous iodide