Standard Article

Castro-Stephens Coupling

(Stephens-Castro Coupling, Castro Coupling)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr136

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Castro-Stephens Coupling. Comprehensive Organic Name Reactions and Reagents. 136:619–623.

Publication History

  1. Published Online: 15 SEP 2010

Chemistry Terms

Choose one or more boxes to highlight terms.

Abstract

The preparation of arylacetylenes by the coupling of cuprous acetylides with aryl halides in boiling pyridines is generally known as the Castro–Stephens coupling. Currently, this coupling is one of the most commonly used methods for the synthesis of aryl acetylenes. Moreover, under the Castro-Stephens coupling condition, acetylenes also couple with vinyl halides or even allyl halides and amines, by which indoles are formed in the coupling with amines.

Keywords:

  • aryl halides;
  • aryl acetylenes;
  • vinyl halide;
  • cuprous iodide