Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Chan Rearrangement. Comprehensive Organic Name Reactions and Reagents. 137:624–626.
- Published Online: 15 SEP 2010
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The Chan rearrangement is a base-induced rearrangement of α-acyloxy-acetates to α-hydroxy-β-keto-esters and under similar conditions amino ketone can also be prepared. This reaction helps to assemble an array of three contiguous oxygenated carbons and has been applied to the syntheses of diazonamide A, aplasmomycin, boromycin, etc.
- α-hydroxy-β-keto ester