Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Clauson-Kaas Reaction. Comprehensive Organic Name Reactions and Reagents. 146:665–668.
- Published Online: 15 SEP 2010
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The synthesis of pyrrole derivative from the condensation between a primary aliphatic or aromatic amine and 2,5-dimethoxy-tetrahydrofuran in the presence of an acid catalyst is generally known as the Clauson–Kaas reaction. This reaction has been used to convert the primary amino group into a pyrrole group, which has been used to prepare a variety of pyrrole derivatives containing different substituents, especially for polycyclic structures containing pyrrole. This reaction either does not work or give only poor yield in the presence of a imidazole group.
- acid catalysts;
- phosphorus pentoxide