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Clauson-Kaas Reaction

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr146

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Clauson-Kaas Reaction. Comprehensive Organic Name Reactions and Reagents. 146:665–668.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of pyrrole derivative from the condensation between a primary aliphatic or aromatic amine and 2,5-dimethoxy-tetrahydrofuran in the presence of an acid catalyst is generally known as the Clauson–Kaas reaction. This reaction has been used to convert the primary amino group into a pyrrole group, which has been used to prepare a variety of pyrrole derivatives containing different substituents, especially for polycyclic structures containing pyrrole. This reaction either does not work or give only poor yield in the presence of a imidazole group.

Keywords:

  • acid catalysts;
  • 2,5-dimethoxy-tetrahydrofuran;
  • 1,4-dichloro-1,4-dimethoxybutane;
  • phosphorus pentoxide