Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Darzens Condensation. Comprehensive Organic Name Reactions and Reagents. 178:841–845.
- Published Online: 15 SEP 2010
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The synthesis of glycidic esters from the condensation between aldehydes or ketones and esters of α-halo-carboxylic acids is known as Darzens condensation. This type of condensation has also been extended to α-halogenated nitriles, sulfoxides, sulfones, sulfoximines, carboxylic amides, etc. The reaction between carbonyl compounds and α-halogenated ketimine is also referred to as the aza-Darzens reaction. This reaction has been modified to occur in the solid-liquid two-phase system using a solid base and catalyst at temperatures higher than 100°C.
- glycidic esters;
- α-halogenated ketimine;
- quaternary salt;