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Darzens Condensation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr178

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Darzens Condensation. Comprehensive Organic Name Reactions and Reagents. 178:841–845.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of glycidic esters from the condensation between aldehydes or ketones and esters of α-halo-carboxylic acids is known as Darzens condensation. This type of condensation has also been extended to α-halogenated nitriles, sulfoxides, sulfones, sulfoximines, carboxylic amides, etc. The reaction between carbonyl compounds and α-halogenated ketimine is also referred to as the aza-Darzens reaction. This reaction has been modified to occur in the solid-liquid two-phase system using a solid base and catalyst at temperatures higher than 100°C.

Keywords:

  • glycidic esters;
  • α-halogenated ketimine;
  • quaternary salt;
  • ethanol