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Darzens Olefin Acylation

(Kondakov Acylation)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr180

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Darzens Olefin Acylation. Comprehensive Organic Name Reactions and Reagents. 180:848–850.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The preparation of β-haloketones via the direct condensation of acyl halides or acyl anhydride and olefins in the presence of Lewis acid is generally known as the Kondakov acylation or Kondakov reaction. However, this reaction is also known as the Darzens acylation of olefin. The subtle differences have been noticed between the Kondakov acylation and the original Darzens reaction condition. Differences from the Fridel–Crafts acylation has also been pointed out for this reaction. This reaction has been found useful for the preparation of β-halo ketones and α,β- or β,γ-unsaturated ketones.

Keywords:

  • β-haloketones;
  • acyl halides;
  • acyl anhydride;
  • Lewis acid catalysts