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Davidson Oxazole Cyclization

(Davidson Cyclization)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr182

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Davidson Oxazole Cyclization. Comprehensive Organic Name Reactions and Reagents. 182:855–857.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The preparation of substituted oxazole by condensation of O-acylacylion with ammonia or ammonium acetate is known as Davidson oxazole cyclization. This reaction is found most suitable for 2,4,5-trisubstituted oxazole or oxazoles with an aromatic substituent at C-5,whereas it works poorly for the preparation of 2,4-disubstituted or monosubstituted oxazoles. The study finds that the cyclization to form oxazole does not occur when ammonia or ammonium acetate is replaced by organic amines.

Keywords:

  • 2,4,5-trisubstituted oxazoles;
  • cyclization;
  • o-acylacylion;
  • organic amines