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Decker-Becker Secondary Amine Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr184

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Decker-Becker Secondary Amine Synthesis. Comprehensive Organic Name Reactions and Reagents. 184:862–864.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of secondary amine by the condensation of primary amines with aldehydes to form an imine intermediate, which then reacts with alkyl halides via alkylation to finally afford secondary amines after hydrolysis, is generally referred to as Decker-Becker secondary amine synthesis and also known as Forster reaction. The study finds that use of methyl halides gives satisfactory results. This reaction has been used in the preparation of secondary amines, such as alkyl (aryl) methyl amines.

Keywords:

  • alkyl halides;
  • methyl halides;
  • alkyl (aryl) methyl amines;
  • primary amines