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Ehrlich-Sachs Reaction

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr208

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Ehrlich-Sachs Reaction. Comprehensive Organic Name Reactions and Reagents. 208:964–966.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The condensation between compounds of active methylene groups and aromatic nitroso molecules is generally known as the Ehrlich–Sachs reaction. The study finds that a base can trigger this reaction and two competing products, the dehydrate azomethine derivative (or Schiff base) and the oxidized nitrone derivative, are formed during the reaction. This reaction has an importance in the preparation of azomethine derivatives, which are used in the dye and drug industry.

Keywords:

  • aryl alkyl ketones;
  • sodium carbonate;
  • Schiff base;
  • methylene group