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Einhorn Acylation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr209

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Einhorn Acylation. Comprehensive Organic Name Reactions and Reagents. 209:967–970.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The acylation of alcohols using anhydride or acyl halide in a tertiary amine such as pyridine is known as the Einhorn acylation. The tertiary amines have been identified as both nucleophilic acylation catalyst and acid scavenger. Numerous highly nucleophilic tertiary amines have been employed for this reaction. This reaction has been applied in the preparation of esters from alcohols and acylation reagents.

Keywords:

  • tertiary amines;
  • pyridine;
  • triethylamine;
  • 4-(dimethylamino)pyridine (DMAP)